[Metabolomics] CPC Metabolism Downunder seminar/webinar series: Friday 1st April

[Ben Crossett]

Dear Metabolomics Colleagues,

The CPC Metabolism Downunder seminar/webinar series is back:

9-10am Friday 1 April 2022
Human Cardiac Metabolism: Looking Beyond Sugar and Fat<https://cpc-comms.sydney.edu.au/link/id/zzzz623795de48e85022Pzzzz528e7faa0ff02240/page.html> | Professor Zoltan Arany and Dr Danielle Murashige

The heart has a continuously high demand for ATP in order to sustain lifelong contraction. It is the most metabolically active tissue in the human body. Mounting evidence indicates that the failing heart is an "engine out of fuel" that fails to use fuel appropriately to satisfy its metabolic demands. The subject of metabolic reprogramming in heart failure has undergone intense study for decades, and therapeutic metabolic interventions have long been proposed as novel therapies for HF. However, our understanding of metabolic reprogramming in HF remains incomplete, especially in humans, and effective metabolic therapies have not yet been achieved.

We will briefly review here historical data on cardiac metabolism, and then present in detail two studies, one published and one not. In the first, to quantitatively capture the metabolic fuel use of the beating human heart in health and disease, we performed metabolomics on blood from artery, coronary sinus, and femoral vein, from 80 patients with preserved cardiac function and 40 patients with reduced cardiac function.

In the second, we integrate plasma and cardiac tissue metabolomics of 678 metabolites, genome-wide RNAseq, and global proteomic studies, to provide a comprehensive depiction of metabolic status in 89 explanted human hearts from 40 patients with end-stage heart failure compared to 49 non-failing donors. Together, these data portray a comprehensive landscape of metabolism in human failing and non-failing hearts and provide insight into mechanisms contributing to the bioenergetic defect of failing hearts.

Kind regards,

Ben

Dr Ben Crossett | Associate Director
The University of Sydney
DVC Research, Sydney Mass Spectrometry

We are hiring - apply here<https://protect-au.mimecast.com/s/PnhFCANpgjC939owQcGCe-z?domain=tinyurl.com> before 3rd April.

Office 4110, The Hub D17 | The University of Sydney | NSW | 2006
+61 2 9351 6010
ben.crossett at sydney.edu.au<mailto:ben.crossett at sydney.edu.au>  |  https://protect-au.mimecast.com/s/Lv8ACBNqjlCV9VmwGf6a035?domain=sydney.edu.au <https://protect-au.mimecast.com/s/Yyx-CD1vlpTBKBmE9cAMK69?domain=sydney.edu.au>

CRICOS 00026A
This email plus any attachments to it are confidential. Any unauthorised use is strictly prohibited. If you receive this email in error, please delete it and any attachments.


-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mailman.sydney.edu.au/pipermail/metabolomics/attachments/20220320/498a94c6/attachment.html>