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<p class="MsoNormal">Dear Metabolomics Colleagues, <o:p></o:p></p>
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<p class="MsoNormal">The CPC Metabolism Downunder seminar/webinar series is back:
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<p class="MsoNormal"><strong><span style="font-size:10.5pt;font-family:"Arial",sans-serif">9–10am Friday 1 April 2022</span></strong><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><br>
<a href="https://cpc-comms.sydney.edu.au/link/id/zzzz623795de48e85022Pzzzz528e7faa0ff02240/page.html" target="_blank"><span style="color:#E64626">Human Cardiac Metabolism: Looking Beyond Sugar and Fat</span></a> | Professor Zoltan Arany and Dr Danielle Murashige
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<p class="MsoNormal">The heart has a continuously high demand for ATP in order to sustain lifelong contraction. It is the most metabolically active tissue in the human body. Mounting evidence indicates that the failing heart is an “engine out of fuel” that
fails to use fuel appropriately to satisfy its metabolic demands. The subject of metabolic reprogramming in heart failure has undergone intense study for decades, and therapeutic metabolic interventions have long been proposed as novel therapies for HF. However,
our understanding of metabolic reprogramming in HF remains incomplete, especially in humans, and effective metabolic therapies have not yet been achieved.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">We will briefly review here historical data on cardiac metabolism, and then present in detail two studies, one published and one not. In the first, to quantitatively capture the metabolic fuel use of the beating human heart in health and
disease, we performed metabolomics on blood from artery, coronary sinus, and femoral vein, from 80 patients with preserved cardiac function and 40 patients with reduced cardiac function.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">In the second, we integrate plasma and cardiac tissue metabolomics of 678 metabolites, genome-wide RNAseq, and global proteomic studies, to provide a comprehensive depiction of metabolic status in 89 explanted human hearts from 40 patients
with end-stage heart failure compared to 49 non-failing donors. Together, these data portray a comprehensive landscape of metabolism in human failing and non-failing hearts and provide insight into mechanisms contributing to the bioenergetic defect of failing
hearts.<o:p></o:p></p>
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<p class="MsoNormal">Kind regards, <o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Ben<o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:8.0pt;font-family:"Arial",sans-serif;color:#4D4D4D;mso-fareast-language:EN-AU"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:8.0pt;font-family:"Arial",sans-serif;color:#4D4D4D;mso-fareast-language:EN-AU">Dr Ben Crossett</span></b><span style="font-size:8.0pt;font-family:"Arial",sans-serif;color:#4D4D4D;mso-fareast-language:EN-AU"> |
Associate Director </span><span style="color:#4D4D4D;mso-fareast-language:EN-AU"><o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:8.0pt;font-family:"Arial",sans-serif;color:#4D4D4D;mso-fareast-language:EN-AU">The University of Sydney</span></b><span style="color:#4D4D4D;mso-fareast-language:EN-AU"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:8.0pt;font-family:"Arial",sans-serif;color:#4D4D4D;mso-fareast-language:EN-AU">DVC Research, Sydney Mass Spectrometry
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</span><span style="font-size:8.0pt;font-family:"Arial",sans-serif;color:red;mso-fareast-language:EN-AU"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:8.0pt;font-family:"Arial",sans-serif;color:red;mso-fareast-language:EN-AU">We are hiring –
<a href="https://protect-au.mimecast.com/s/PnhFCANpgjC939owQcGCe-z?domain=tinyurl.com"><span style="color:#0563C1">apply here</span></a> before 3<sup>rd</sup> April.</span><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#4D4D4D;mso-fareast-language:EN-AU"><br>
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<p class="MsoNormal"><span style="font-size:8.0pt;font-family:"Arial",sans-serif;color:#4D4D4D;mso-fareast-language:EN-AU">Office 4110, The Hub D17 | The University of Sydney | NSW | 2006<b><br>
</b>+61 2 9351 6010 <br>
</span><b><span style="font-size:8.0pt;font-family:Consolas;color:#4D4D4D;mso-fareast-language:EN-AU"><a href="mailto:ben.crossett@sydney.edu.au" target="_blank"><span style="font-family:"Arial",sans-serif;color:#4D4D4D;text-decoration:none">ben.crossett@sydney.edu.au</span></a></span></b><b><span style="font-size:8.0pt;font-family:"Arial",sans-serif;color:#4D4D4D;mso-fareast-language:EN-AU">
| <a href="https://protect-au.mimecast.com/s/Yyx-CD1vlpTBKBmE9cAMK69?domain=sydney.edu.au" target="_blank"><span style="color:#4D4D4D;text-decoration:none">sydney.edu.au/mass-spectrometry
</span></a><o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:8.0pt;font-family:"Arial",sans-serif;color:#4D4D4D;mso-fareast-language:EN-AU"> <o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:8.0pt;font-family:"Arial",sans-serif;color:#4D4D4D;mso-fareast-language:EN-AU">CRICOS 00026A<br>
This email plus any attachments to it are confidential. Any unauthorised use is strictly prohibited. If you receive this email in error, please delete it and any attachments.</span><span style="color:#4D4D4D;mso-fareast-language:EN-AU"><o:p></o:p></span></p>
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