[Metabolomics] Metabolomics Seminar: Tue 18th June, 4pm, CPC

[Ben Crossett]

Dear Colleagues,

Sydney Mass Spectrometry, in conjunction with the Charles Perkins Centre and the Brain and Mind Centre, is holding a special seminar on  metabolomics, read on for more details summaries.  Please circulate the attached flyer were possible.

Who: Dr. Curt Fischer, Stanford.
What:  LC-MS-based discovery of bioactive small molecules
Where: Level 6 Seminar Room, Charles Perkins Centre, University of Sydney
Abstract:
In 2000 scientists announced substantial completion of the human genome sequence, and in 2002 electrospray mass spectrometry won a nobel prize.  Nearly two decades have passed since then, but we remain without a complete inventory of the bioactive small molecules used by humans and other organisms.  Using untargeted metabolomics, an approach where experiment rather than experimenter chooses the compounds to study, I will show how mass spectrometry-based "untargeted" and "semi-targeted" metabolomics, especially when coupled to genetic perturbations or "synthetic biology", has been used to identify previously unknown, bioactive small molecules in diverse systems including bird feathers, plant tissue, stool samples, and engineered microorganisms.  An illustrative example comes from the study of plant and fungal polyacetylenes.  By adapting synthetic chemistry methods to our metabolomics workflow, we were able to improve LC-MS detection methods for polyacetylenes, which resulted in the discovery of a previously unknown metabolic pathway in plants and previously unknown bioactive compounds in dietary fungi.
Biography:
Dr. Curt Fischer joined Stanford ChEM-H and Stanford's Genome Technology Center in 2015 as a research engineer and now serves as the Head of the Metabolic Chemistry Analysis Center. He has applied mass-spectrometry-based metabolomics and proteomics techniques to human gut microbes, extremopholic microbial communities, plant tissues, and clinical samples.  His interests include in the creation and application of new methods for understanding the biology of small molecules, especially in untargeted metabolomics.  Dr. Fischer earned a Ph.D. in Chemical Engineering from MIT, performed post-doctoral scholarship at UC Berkeley, and then spent 4 years at synthetic biology startup Ginkgo Bioworks, where was their 2nd full-time hire and led a variety of publicly and privately funded projects in synthetic biology, metabolic engineering, and metabolomics.

Kind regards,

Ben

Dr Ben Crossett | Manager
The University of Sydney
DVC Research, Sydney Mass Spectrometry
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