[Metabolomics] Metabolomics Digest, Vol 13, Issue 1

Wed Sep 6 16:11:58 AEST 2017

Thanks for the information. Two of the presentations relate to kinetic studies based on stable isotope administration to humans. In the past, we have been unable to satisfy local Ethics Committee requirements as to the certified sterile preparation of IV infusions for this purpose. If there is sufficient demand, it may be possible to encourage a local (Sydney) manufacturer to fill this niche. Regards David

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From: Metabolomics [metabolomics-bounces at mailman.sydney.edu.au] on behalf of metabolomics-request at mailman.sydney.edu.au [metabolomics-request at mailman.sydney.edu.au]
Sent: Wednesday, 6 September 2017 12:47 PM
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Subject: Metabolomics Digest, Vol 13, Issue 1

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Today's Topics:

   1. Darren Creek - Centenary Institute Tuesday Seminar August
      29th (Ben Crossett)
   2. FW: Final Reminder! Webinar: Let?s Chew the Fat with Orbitrap
      MS - Enabling Lipid Metabolic Flux Studies and Structural
      Elucidation of Lipids with Ultra High Resolution and UVPD
      Fragmentation (Ben Crossett)

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Message: 1
Date: Tue, 22 Aug 2017 22:54:45 +0000
From: Ben Crossett <ben.crossett at sydney.edu.au>
To: "Metabolomics at mailman.sydney.edu.au"
        <Metabolomics at mailman.sydney.edu.au>
Subject: [Metabolomics] Darren Creek - Centenary Institute Tuesday
        Seminar August 29th
Message-ID: <91043E40EC58C34BB59CEF09BC71C18701BDF41ACA at ex-mbx-pro-04>
Content-Type: text/plain; charset="utf-8"

Hi Folks,

Like busses, you wait ages and then three turn up at once!

Next Tuesday we have another metabolomics talk:

12.00pm to 1.00pm
Tuesday 29th August, 2017

Dr Darren Creek
Senior Lecturer, (Career Development Fellow)
Monash Institute of Pharmaceutical Sciences

"Discovering Mechanisms of Drug Action and Resistance with Metabolomics"

The Centenary Institute
Lecture Theatre, Level 6,
Building 93, Royal Prince Alfred Hospital Grounds

Lunch will be provided for attendees following the seminar.

Darren will be around most of the day, if you would like to meet up with him contact:  Anthony Don [mailto:a.don at centenary.org.au]

About the speaker:

Dr Darren Creek is a Senior Lecturer, NHMRC Career Development Fellow and head of the pharmaceutical metabolomics laboratory at the Monash Institute of Pharmaceutical Sciences. He completed his PhD at Monash University in 2007, and performed post-doctoral research in Uganda, Scotland and Australia working on antimalarial drug discovery and clinical trials, before focusing on metabolomics studies of tropical parasites.He developed several novel analytical methods and software tools for the metabolomics  eld, and discovered novel pathways and drug mechanisms in protozoan parasites. Dr Creek?s laboratory currently uses metabolomics and proteomics to understand mechanisms of drug action and resistance for cancer and infectious diseases, with a major focus on African trypanosomiasis and malaria. Darren continues to develop novel metabolomics methods to advance the  eld and is a Director of the international Metabolomics Society.

About the seminar:

Drug resistance poses a major threat to the management of infectious diseases, and new drugs are urgently required for many common infections.Unfortunately, the development of new drugs is often hampered by a lack of knowledge regarding the mechanisms of action and resistance of existing drugs,and of new lead compounds. Recent advances in post-genomic technologies, including metabolomics and proteomics, provide an opportunity for unbiased analysis of the impact of drug treatment on cellular biochemistry, allowing discovery of previously unanticipated mechanisms of drug action and resistance.
We have used these technologies to discover the mode of action of over 100 compounds that target the causative agents of malaria and African trypanosomiasis. Furthermore, multi-omic analysis of malaria parasites resistant to the  rst-, and last-line antimalarials, the artemisinins, revealed depleted levels of a key biomarker protein, and differential regulation of haemoglobin digestion and glutathione synthesis. These  ndings provide opportunities for clinical translation of new biomarkers of drug resistance, and provide direct evidence of the resistance mechanisms which may be exploited to enhance the activity of
these important medicines.

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Message: 2
Date: Wed, 6 Sep 2017 02:47:41 +0000
From: Ben Crossett <ben.crossett at sydney.edu.au>
To: "Metabolomics at mailman.sydney.edu.au"
        <Metabolomics at mailman.sydney.edu.au>
Cc: Stuart Cordwell <stuart.cordwell at sydney.edu.au>
Subject: [Metabolomics] FW: Final Reminder! Webinar: Let?s Chew the
        Fat with Orbitrap MS - Enabling Lipid Metabolic Flux Studies and
        Structural Elucidation of Lipids with Ultra High Resolution and UVPD
        Fragmentation
Message-ID: <91043E40EC58C34BB59CEF09BC71C18701BDF6D906 at ex-mbx-pro-04>
Content-Type: text/plain; charset="utf-8"

Hi Guys,

Gavin Reed is an excellent speaker and certainly knows his stuff so I would recommend registering for this webinar.

The timing works well the delivery last week of a Q Exactive HFX which will be dedicated to lipidomics analysis.  The second half of the talk is on ultraviolet photodissociation, a relatively new techniques but one which shows great promise and is certainly something on our shopping list of techniques we would like to see established here in Sydney.

Kinds regards,

Ben

From: C&EN Webinars [mailto:cenwebinar at acs.org]
Sent: Tuesday, 5 September 2017 11:13 PM
To: Ben Crossett <ben.crossett at sydney.edu.au>
Subject: Final Reminder! Webinar: Let?s Chew the Fat with Orbitrap MS - Enabling Lipid Metabolic Flux Studies and Structural Elucidation of Lipids with Ultra High Resolution and UVPD Fragmentation

Determining lipid turnover rates (lipid metabolic flux) based on stable isotope labeling and isotope dilution analysis remains a challenging task. Deuterated water is a commonly used reagent for these experiments as it is easily incorporated into metabolic pathways and simplifies the peak assignments compared to using heavier isotopes like 18O...
If you have trouble viewing this email, read the online version<https://protect-au.mimecast.com/s/Db1pBJUwR3axcW?domain=app.acspubs.org>.

[C&EN]

Final Reminder. Register Now.

Let?s Chew the Fat with Orbitrap MS - Enabling Lipid Metabolic Flux Studies and Structural Elucidation of Lipids with Ultra High Resolution and UVPD Fragmentation

[C&EN]

September 07, 2017

[C&EN]

USA 8:00am PDT, 11:00am EDT,
16:00 BST, 17:00 CEST

[Rounded Rectangle: REGISTER NOW]

Speakers

[C&EN]

Matt Mitsche, PhD.,

Postdoctoral Fellow,
UT Southwestern Medical Center, TX

[C&EN]

Gavin E. Reid, PhD.,

Professor of Bioanalytical Chemistry,
University of Melbourne

[C&EN]

Overview

The first part of this webinar describes the use of ultra-high resolution MS to baseline-resolve these two peaks, greatly improving the selectivity and detection limit of this quantitative technique.

The second part of the webinar discusses the introduction of a unique fragmentation mode, ultraviolet photodissociation (UVPD) for unambiguous characterization of various lipid classes thereby representing a major breakthrough for lipid research. Locating a double bond in the acyl chain of lipid molecules used to be impossible with soft fragmentation techniques such as CID or HCD...

[Rounded Rectangle:  Read More]

Sponsors:

[https://protect-au.mimecast.com/s/87W8BlULJbeOca?domain=images.acspubs.org]

Key Learning Objectives

[C&EN]

Learn about ultra-high resolution MS that allow fluxomics analysis of lipids with sensitivity comparable to radioactivity tracing.

[C&EN]

Learn how applying UVPD fragmentation to lipids can aid in the localization of their site(s) of unsaturation, assignment of complex backbone and headgroup identities, and the differentiation of isomeric lipids within complex mixtures.

Who Should Attend:

Researchers focused on lipidomics and metabolomics analysis.

Researchers using stable isotope-labeling studies for pathway analysis.

Researchers performing structure elucidation and characterization of lipid species or other small molecule endogenous metabolites.

[Rounded Rectangle: REGISTER NOW]

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