[Metabolomics] FW: Final Reminder! Webinar: Let’s Chew the Fat with Orbitrap MS - Enabling Lipid Metabolic Flux Studies and Structural Elucidation of Lipids with Ultra High Resolution and UVPD Fragmentation

[Ben Crossett]

Hi Guys,

Gavin Reed is an excellent speaker and certainly knows his stuff so I would recommend registering for this webinar.

The timing works well the delivery last week of a Q Exactive HFX which will be dedicated to lipidomics analysis.  The second half of the talk is on ultraviolet photodissociation, a relatively new techniques but one which shows great promise and is certainly something on our shopping list of techniques we would like to see established here in Sydney.

Kinds regards,

Ben

From: C&EN Webinars [mailto:cenwebinar at acs.org]
Sent: Tuesday, 5 September 2017 11:13 PM
To: Ben Crossett <ben.crossett at sydney.edu.au>
Subject: Final Reminder! Webinar: Let’s Chew the Fat with Orbitrap MS - Enabling Lipid Metabolic Flux Studies and Structural Elucidation of Lipids with Ultra High Resolution and UVPD Fragmentation

Determining lipid turnover rates (lipid metabolic flux) based on stable isotope labeling and isotope dilution analysis remains a challenging task. Deuterated water is a commonly used reagent for these experiments as it is easily incorporated into metabolic pathways and simplifies the peak assignments compared to using heavier isotopes like 18O...
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[C&EN]


Final Reminder. Register Now.





Let’s Chew the Fat with Orbitrap MS - Enabling Lipid Metabolic Flux Studies and Structural Elucidation of Lipids with Ultra High Resolution and UVPD Fragmentation


[C&EN]

September 07, 2017

[C&EN]

USA 8:00am PDT, 11:00am EDT,
16:00 BST, 17:00 CEST

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Speakers


[C&EN]

Matt Mitsche, PhD.,

Postdoctoral Fellow,
UT Southwestern Medical Center, TX



[C&EN]

Gavin E. Reid, PhD.,

Professor of Bioanalytical Chemistry,
University of Melbourne




[C&EN]

Overview


The first part of this webinar describes the use of ultra-high resolution MS to baseline-resolve these two peaks, greatly improving the selectivity and detection limit of this quantitative technique.

The second part of the webinar discusses the introduction of a unique fragmentation mode, ultraviolet photodissociation (UVPD) for unambiguous characterization of various lipid classes thereby representing a major breakthrough for lipid research. Locating a double bond in the acyl chain of lipid molecules used to be impossible with soft fragmentation techniques such as CID or HCD...

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Key Learning Objectives

[C&EN]

Learn about ultra-high resolution MS that allow fluxomics analysis of lipids with sensitivity comparable to radioactivity tracing.

[C&EN]

Learn how applying UVPD fragmentation to lipids can aid in the localization of their site(s) of unsaturation, assignment of complex backbone and headgroup identities, and the differentiation of isomeric lipids within complex mixtures.


Who Should Attend:



Researchers focused on lipidomics and metabolomics analysis.



Researchers using stable isotope-labeling studies for pathway analysis.



Researchers performing structure elucidation and characterization of lipid species or other small molecule endogenous metabolites.




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