[Metabolomics] CPC Metabolism Downunder Seminar, 9am this Thursday.

[Ben Crossett]

Metabolism Downunder

9:00-10:00am | Thursday 6 April

IFITM3 in Platelets Mediates Cargo Trafficking during Inflammatory Stress

When: 9-10am | Thursday 6 April 2023

Zoom Meeting ID: 893 4671 3883

Speaker | Professor Matthew Rondina, Professor of Medicine and Pathology, University of Utah Eccles Institute of Human Genetics

Abstract
Platelets and megakaryocytes are critical players in immune responses. While anucleate, the platelet transcriptome and proteome are altered during clinical and experimental sepsis. Among the upregulated genes, IFN-induced transmembrane protein 3 (IFITM3), an IFN-responsive gene that restricts viral replication was studied in detail. IFN stimulation enhanced fibrinogen endocytosis in megakaryocytes and platelets in an IFITM-dependent fashion. IFITM3 interacts with clathrin and αIIb to alter plasma membrane localization into lipid rafts. In vivo IFN administration increased fibrinogen endocytosis, platelet reactivity, and thrombosis in an IFITM-dependent manner. Consistent with murine findings, platelets from patients with nonviral sepsis had increases in platelet IFITM3 expression, fibrinogen content, and hyperreactivity.
These and other data identifying IFITM3 as a regulator of cargo trafficking during inflammatory stress will be discussed

Dr Ben Crossett | Associate Director
The University of Sydney
DVC Research, Sydney Mass Spectrometry

Office 4110, The Hub D17 | The University of Sydney | NSW | 2006
+61 2 9351 6010
ben.crossett at sydney.edu.au<mailto:ben.crossett at sydney.edu.au>  |  sydney.edu.au/mass-spectrometry <http://sydney.edu.au/mass-spectrometry>

CRICOS 00026A
This email plus any attachments to it are confidential. Any unauthorised use is strictly prohibited. If you receive this email in error, please delete it and any attachments.

-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mailman.sydney.edu.au/pipermail/metabolomics/attachments/20230403/7f844229/attachment.htm>