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<title>The Evolution of Human Aging. Mael Lemoine - University Bordeaux</title>
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<h1 align="center" style="text-align:center"><span style="font-size:12.0pt;color:black">Professor Maël Lemoine</span><br>
<a href="https://protect-au.mimecast.com/s/f3djCzvkyVCMng2l5Hgtwqa?domain=researchgate.net"><span class="org"><span style="font-size:10.5pt;color:black;font-weight:normal">University of Bordeaux</span></span><span style="font-size:10.5pt;color:black;font-weight:normal"> · Department
of Life and Health Sciences</span></a><o:p></o:p></h1>
<p class="MsoNormal" align="center" style="text-align:center;line-height:150%"><strong><span style="font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif;color:black">The Evolution of Human Aging.</span></strong><span style="font-size:13.0pt;line-height:150%;font-family:"Helvetica",sans-serif;color:black"><br>
<strong><span style="font-family:"Helvetica",sans-serif">Geroscience is a new agenda in medical research that explores the possibility of intervention on generic mechanisms of aging to postpone the onset of age-related diseases. One danger for this agenda is
to get lost in the complexity of the interactions between mechanisms of aging. Only a relevant theoretical framework can help.</span></strong><b><br>
<strong><span style="font-family:"Helvetica",sans-serif">Three important approaches to the biology of aging have been: </span></strong><br>
<strong><span style="font-family:"Helvetica",sans-serif">1) the evolutionary theory of aging (ETA), which established general mechanisms to explain the absence of elimination of aging, like antagonistic pleiotropy and the disposable soma theory; </span></strong><br>
<strong><span style="font-family:"Helvetica",sans-serif">2) biodemography, which studies patterns of senescence and non-senescence in different species;</span></strong><br>
<strong><span style="font-family:"Helvetica",sans-serif">3 the molecular biology of aging (MBA), which investigates the so-called "hallmarks of aging" one by one or their interactions two by two. </span></strong><br>
<strong><span style="font-family:"Helvetica",sans-serif"> </span></strong><br>
<strong><span style="font-family:"Helvetica",sans-serif">I propose a new, hybrid approach based on the investigation of the order of apparition, during evolution, of the different mechanisms of aging that are conserved in humans, as a basis to a multilayer
evolutionary view of aging (MEVA). I sketch the preliminary results and draw the consequences on received views on aging and on geroscience in particular.</span></strong></b></span><span style="font-size:13.0pt;line-height:150%;font-family:"Helvetica",sans-serif;color:#DB132A"><br>
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<p class="MsoNormal" style="line-height:150%"><strong><span style="font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif;color:black">WHERE:
<a href="http://Meeting%20URL:%20%09https:/uni-sydney.zoom.us/j/87309646911%20%20%20Meeting%20ID:%20%09873%200964%206911" target="_blank">
<span style="color:#101010;font-weight:normal">ZOOM </span></a></span></strong><span style="font-size:13.0pt;line-height:150%;font-family:"Helvetica",sans-serif;color:#DB132A"><o:p></o:p></span></p>
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<p class="MsoNormal"><a href="https://uni-sydney.zoom.us/j/87309646911" target="_blank"><span style="color:#101010">https://uni-sydney.zoom.us/j/87309646911</span></a><o:p></o:p></p>
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<p class="MsoNormal">873 0964 6911<o:p></o:p></p>
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<p class="MsoNormal" style="line-height:150%"><strong><span style="font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif;color:black">WHEN: MONDAY 24TH MAY 2021</span></strong><b><span style="font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif;color:black"><br>
<strong><span style="font-family:"Helvetica",sans-serif">START: 5.00 PM</span></strong></span></b><span style="font-size:13.0pt;line-height:150%;font-family:"Helvetica",sans-serif;color:#DB132A"><o:p></o:p></span></p>
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